Serie de casos de sangrado intraluminal postoperatorio en colectomía izquierda / Case series of postoperative intraluminal bleeding in left colectomy

Introducción: El sangrado digestivo intraluminal postoperatorio es una entidad poco frecuente y su manifestación clínica no difiere de la hemorragia digestiva baja de otra etiología. A pesar de que su presentación más habitual es la hematoquecia autolimitada en la primera deposición, en un discreto porcentaje puede requerir transfusiones, tratamiento endoscópico, hemodinámico, o incluso cirugía. Objetivo: Analizar los pacientes con sangrado digestivo intraluminal postoperatorio tratados en un centro de alta complejidad y realizar una revisión bibliográfica del tema. Diseño: Estudio retrospectivo, descriptivo. Material y métodos: Pacientes con sangrado anastomótico durante el post operatorio inmediato de una colectomía izquierda, operados en el Servicio de Cirugía General y Coloproctología desde enero del 2017 a diciembre del 2021. Las variables estudiadas fueron edad, sexo, anticoagulación y su causa, descenso de hemoglobina, cirugía realizada y su indicación, vía de abordaje, configuración de la anastomosis, electividad de la cirugía, complicaciones, días de internación y manejo terapéutico. Resultados: Se incluyeron 4 pacientes con una edad media de 72 (rango 54-87) años y una distribución por sexo de 1:1. En todos la colectomía izquierda fue programada y en 3 el abordaje fue laparoscópico. La anastomosis fue termino-terminal con sutura mecánica circular. Todos los pacientes presentaron sangrado en las primeras 24 horas postoperatorias. El tratamiento fue decidido de acuerdo a la condición hemodinámica: en los 2 pacientes con estabilidad hemodinámica fue suficiente el tratamiento conservador con reanimación y transfusiones. Los otros 2 que presentaron inestabilidad hemodinámica requirieron manejo intervencionista con endoscopía rígida, videocolonoscopía y cirugía. Conclusión: El sangrado intraluminal es una complicación poco frecuente de la anastomosis colorrectal que requiere manejo intervencionista solo en los pacientes que presentan inestabilidad hemodinámica. (AU)

Introduction: Postoperative intraluminal gastrointestinal bleeding is a rare entity and its clinical manifestation does not differ from lower gastro-intestinal bleeding of another etiology. Despite the fact that its most common presentation is self-limited hematochezia at the first stool, in a small percentage it may require transfusions, endoscopic or hemodynamic management, or even surgery. Aim: To analyze the patients with postoperative intraluminal gastrointestinal bleeding treated in a tertiary center and to carry out a bibliographic review of the subject. Design: Retrospective descriptive study. Material and methods: Patients with immediate postoperative anastomotic bleeding from a left colectomy, operated on at the General Surgery and Coloproctology Service from January 2017 to December 2021 were included. The variables recorded were age, sex, anticoagulation and its cause, decrease in hemoglobin, procedure performed and its indication, surgical approach, type of anastomosis, electiveness of surgery, complications, hospital stay and management. Results: Four patients with a mean age of 72 (range 54-87) years and a 1:1 gender distribution were included. All procedures were elective and 3 laparoscopic. All anastomoses were performed end-to-end with a circular stapler. All patients presented bleeding in the first 24 postoperative hours. The treatment was decided according to the hemodynamic condition; patients with hemodynamic stability (2) received medical treatment while those with hemodynamic instability (2) required interventional management with rigid endoscopy, colonoscopy and surgery. Conclusion: Intraluminal bleeding is a rare complication of colorectal anastomosis that requires interventional management only in patients with hemodynamic instability. (AU)

A Retrospective Analysis of Peroperative Risk Factors Associated with Posttonsillectomy Reactionary Hemorrhage in a Teaching Hospital

Introduction: Tonsillectomy is one of the most common otolaryngology procedures performed worldwide. It is also one of the first procedures learnt by residents during their training period. Although tonsillectomy is viewed relatively as a low-risk procedure, it can be potentially harmful because of the chance of posttonsillectomy hemorrhage. Objective: The objective of the present study is to analyze the effects of peroperative factors and experience of the surgeon on the incidence and pattern of posttonsillectomy reactionary hemorrhage. Methods: A retrospective review of medical charts was performed from 2014 to 2017 in a tertiary care hospital. A total of 1,284 patients who underwent tonsillectomy and adenoidectomy were included in the study. The parameters assessed were experience of the surgeon, operating time, intraoperative blood loss, difference in mean arterial pressure (MAP) and pulse rate. Results: A total of 23 (1.79%) out of the 1,284 patients had reactionary hemorrhage. Out of those 23, 16 (69.5%) patients had been operated on by trainees, while 7 (30.5%) had been operated on by consultants (p = 0.033, odds ratio [OR] = 0.04). Operating time, intraoperative blood loss, difference in MAP and pulse rate were significantly higher in the reactionary hemorrhage group, and showed a positive association with risk of hemorrhage (p < 0.05; OR >1). Re-exploration to control the bleeding was required in 10 (76.9%) out of the 23 cases. Conclusion: The experience of the surgeon experience and peroperative factors have an association with posttonsillectomy hemorrhage. Close surveillance and monitoring of the aforementioned peroperative factors will help in the identification of patients at risk of hemorrhage (AU)

Experiencia de un centro colombiano en el tratamiento endovascular de la hemorragia posparto que amenaza la vida / Experience of a Colombian center in the endovascular management of life-threatening postpartum hemorrhage

Resumen Introducción. La hemorragia posparto es la primera causa de morbimortalidad materna en el mundo y las laceraciones son la segunda causa en frecuencia. Su tratamiento temprano y apropiado es clave para obtener buenos resultados, y la oclusión endovascular de los vasos pélvicos se cuenta entre las opciones terapéuticas. Objetivo. Describir la experiencia del tratamiento con la 'embolización' (sic) arterial de los vasos pélvicos. Materiales y métodos. Se trató de un estudio retrospectivo del tipo de serie de casos basado en el registro institucional de la Fundación Valle del Lili, Cali, Colombia, en el que se incluyeron las pacientes con hemorragia posparto atendidas entre el 1º de enero del 2011 y el 31 de octubre del 2016. Resultados. De las 430 pacientes con diagnóstico de hemorragia posparto, 11 fueron sometidas a la 'embolización' de los vasos pélvicos. De este grupo, 10 pacientes tuvieron parto vaginal con laceraciones vaginales complejas, y la mayoría (9 casos, 82 %) fue remitida por otras instituciones de menor complejidad después de 20,5 horas. Las arterias ocluidas frecuentemente fueron la vaginal superior y la pudenda interna. Ninguna paciente presentó complicaciones asociadas al procedimiento y solo dos presentaron sangrado recurrente. Tres pacientes requirieron histerectomía y ninguna murió. Conclusión. El manejo percutáneo es un método de tercera línea, seguro y efectivo para el control de los sangrados de difícil manejo en las pacientes con hemorragia posparto por desgarros perineales complejos. Estos resultados son similares a los reportados en la literatura científica mundial disponible hasta la fecha.

Abstract Introduction: Postpartum hemorrhage is a world-leading cause of morbidity and mortality. Lacerations are the second most frequent cause. Early management with appropriate treatment is essential to obtain adequate outcomes; the endovascular occlusion of pelvic vessels is among the management options. Objective: To describe the management experience with the arterial embolization of pelvic vessels. Materials and methods: We conducted a retrospective case series study based on the institutional registry of Fundación Valle del Lili (Cali, Colombia), which included patients with postpartum hemorrhage admitted between January 1st, 2011 and October 31st, 2016. Results: Out of 430 patients diagnosed with PPH, 11 were subject to embolization of pelvic vessels. Within our group, 10 patients had a vaginal delivery with severe vaginal lacerations; most of them (9 cases, 82%) were referred from other lower-complexity institutions after 20.5 hours. Occlusion was more frequent in the superior vaginal and the internal pudendal arteries. No patients showed complications associated with the procedure and only 2 showed recurrent bleeding while 3 required a hysterectomy, but no deaths occurred. Conclusion: Percutaneous management is a safe and effective third-line method for difficult-management bleedings control in patients with postpartum hemorrhage after a severe perineal tear. These results are similar to case reports published in the worldwide literature available to date.

Embolization of ruptured renal angiomyolipoma in puerpera / Embolização de angiomiolipoma renal roto em puérpera

Abstract Angiomyolipomas (AMLs) are rare benign tumors derived from mesenchymal tissue and composed of varying degrees of adipose tissue, muscle and blood vessels. Renal AMLs (RAMLs) are the result of a sporadic event, and, in most of cases, the diagnosis is usually incidental, but hemorrhage and shock may be present. During pregnancy, the size of AMLs may increase and they may rupture, probably due to the high expression of hormone receptors, and the increase in maternal circulation and abdominal pressure. The authors present a case of a woman with ruptured RAML submitted to urgent endovascular treatment four days after giving birth by cesarean section.

Resumo Angiomiolipomas (AMLs) são tumores benignos raros derivados do tecido mesenquimal, compostos em graus variados de tecido adiposo, muscular e de vasos sanguíneos. Os AMLs renais (AMLRs) resultam de um evento esporádico e, na maioria dos casos, o diagnóstico costuma ser fortuito, mas quadros de hemorragia e choque podem estar presentes. Durante a gestação, os AMLs podem aumentar de tamanho e romper, provavelmente pela altaexpressãodereceptoreshormonais,epeloaumentodacirculaçãomaternaedapressão abdominal. Os autores apresentam um caso de uma paciente com AMLR roto submetida a tratamento endovascular de urgência no quarto dia pós-operatório de uma cesariana.

Puntos de aproximación de pilares en amigdalectomía pediátrica / Pillars´ approach suture points in pediatric tonsillectomy / Pontos de abordagem dos pilares na tonsilectomia pediátrica

INTRODUCCIÓN: A lo largo de los años, varias técnicas de amigdalectomía han sido desarrolladas y modificadas con el fin de reducir su morbimortalidad. Diversos estudios han comparado estas técnicas, no habiendo consenso en cuanto al método con mejores resultados. El objetivo de nuestro trabajo es describir la técnica personal de amigdalectomía y analizar la frecuencia de sangrado y el desarrollo de insuficiencia velopalatina post-quirúrgica en la cirugía con aproximación de pilares. MATERIAL Y MÉTODO: Estudio descriptivo, prospectivo. Se incluyeron pacientes operados de amigdalectomía con amigdalotomo de Daniels, de 3 a 15 años, en el período comprendido desde febrero de 2017 a febrero de 2018, en el sistema de salud Malvinas Argentinas. Se interrogó por sintomatología de sangrado e insuficiencia velopalatina mediante una encuesta de elaboración propia a la semana y al mes post-quirúrgico...

INTRODUCTION: Throughout the years, several tonsillectomy techniques have been developed and modified in order to reduce their morbidity and mortality. Several studies have compared these techniques, and there is no consensus regarding the method with better results. The objective of our study is to describe the personal technique of tonsillectomy and analyze the frequency of bleeding and development of post-surgical velopalatine insufficiency in surgery with abutment approach. MATERIAL AND METHOD: Descriptive, prospective study. We included patients undergoing tonsillectomy with Daniels, from between 3 and 15 years old, from February 2017 to February 2018, in the Malvinas Argentinas hospital. They were interrogated for symptomatology of bleeding and velopalatine insufficiency by through of a self-developed questionnaire one week and one month after surgery…

INTRODUÇÃO: Ao longo dos anos, várias técnicas de amigdalectomia foram desenvolvidas e modificadas para reduzir sua morbidade e mortalidade. Diversos estudos compararam essas técnicas, não havendo consenso em relação ao método com melhores resultados. O objetivo do nosso trabalho é descrever a técnica pessoal de amigdalectomia e analisar a frequência de sangramento e o desenvolvimento de insuficiência velopalatina pós-cirúrgica em cirurgia com abordagem de abutment. MATERIAL E MÉTODO: Estudo descritivo, prospectivo. Foram incluídos pacientes submetidos à tonsilotomia com tonsilectomia de Daniels, de 3 a 15 anos, no período de fevereiro de 2017 a fevereiro de 2018, no sistema de saúde Malvinas Argentinas. Foi interrogado por sintomatologia de hemorragia e insuficiência velopalatine por meio de um questionário autodevelado durante a semana e o mês pós-cirúrgico...

Uso do curativo hemostático de gelatina absorvível no cuidado pós-operatório do pedículo vascular dos retalhos interpolados / Use of absorbable hemostatic gelatin sponge in postoperative care of the vascular pedicle of interpolated flaps

Os retalhos interpolados têm sido um dos mais importantes e funcionais retalhos no arsenal da cirurgia plástica reconstrutiva, tornando-se uma opção segura mesmo nos casos mais difíceis. O pedículo do retalho interpolado necessita de curativo para evitar sangramento e a contaminação local. Este curativo frequentemente falha na prevenção de pequenos sangramentos que ocorrem durante as primeiras 24-48 horas, forçando a troca recorrente do mesmo, em média de três a cinco trocas. A técnica proposta neste trabalho consiste na aplicação direta de uma camada de GELFOAM®, envolto por gaze petrolizada, para prevenção do sangramento da área cruenta do pedículo do retalho, acarretando melhor hemostasia e menos manipulação do pedículo vascular.

Interpolated flaps are among the most important and functional flaps in reconstructive plastic surgery, representing a safe option even in the most difficult cases. The pedicle of the interpolated flap requires a dressing to avoid bleeding and local contamination. This dressing often fails to prevent minor bleedings, which occurs within the first 24-48 hours. As a result, it needs to be continuously changed, from three to five times on average. The technique proposed in this study consists in a direct application of a GELFOAM® layer. This is subsequently wrapped with petroleum gauze to prevent bleeding of the open area in the pedicle flap, improving hemostasis and reducing the manipulation of the vascular pedicle.

Comparison of two technics of cardiopulmonary bypass (conventional and mini CPB) in the trans-and postoperative periods of cardiac surgery / Comparação de duas técnicas de circulação extracorpórea (convencional e mini CEC), nos períodos trans e pós-operatório de cirurgia cardíaca

AbstractObjective:This study aimed to compare the effects of two different perfusion techniques: conventional cardiopulmonary bypass and miniature cardiopulmonary bypass in patients undergoing cardiac surgery at the University Hospital of Santa Maria - RS.Methods:We perform a retrospective, cross-sectional study, based on data collected from the patients operated between 2010 and 2013. We analyzed the records of 242 patients divided into two groups: Group I: 149 patients undergoing cardiopulmonary bypass and Group II - 93 patients undergoing the miniature cardiopulmonary bypass.Results:The clinical profile of patients in the preoperative period was similar in the cardiopulmonary bypass and miniature cardiopulmonary bypass groups without significant differences, except in age, which was greater in the miniature cardiopulmonary bypass group. The perioperative data were significant of blood collected for autotransfusion, which were higher in the group with miniature cardiopulmonary bypass than the cardiopulmonary bypass and in transfusion of packed red blood cells, which was higher in cardiopulmonary bypass than in miniature cardiopulmonary bypass. In the immediate, first and second postoperative period the values of hematocrit and hemoglobin were higher and significant in miniature cardiopulmonary bypass than in the cardiopulmonary bypass, although the bleeding in the first and second postoperative days was higher and significant in miniature cardiopulmonary bypass than in the cardiopulmonary bypass.Conclusion:The present results suggest that the miniature cardiopulmonary bypass was beneficial in reducing the red blood cell transfusion during surgery and showed slight but significant increase in hematocrit and hemoglobin in the postoperative period.

ResumoObjetivo:Este estudo teve como objetivo comparar os efeitos de duas técnicas de perfusão diferentes: convencional (CEC) e mini (MCEC) em pacientes submetidos à cirurgia cardíaca no Hospital Universitário de Santa Maria - RS.Métodos:Foi realizado um estudo retrospectivo, transversal, baseado em dados coletados dos pacientes operados entre 2010 e 2013. Foram analisados ​​os registros de 242 pacientes divididos em dois grupos: Grupo I - 149 pacientes submetidos à circulação extracorpórea e Grupo II - 93 pacientes submetidos à minicirculação extracorpórea.Resultados:O perfil clínico dos pacientes no pré-operatório foi semelhante nos grupos circulação extracorpórea e minicirculação extracorpórea sem diferenças significativas, exceto na idade, maior no grupo minicirculação extracorpórea. Os dados perioperatórios foram significativos de sangue coletadas para autotransfusão, que foram maiores no grupo com minicirculação extracorpórea do que a circulação extracorpórea e na transfusão de concentrado de hemácias, superior em circulação extracorpórea do que em minicirculação extracorpórea. Nos valores pós-operatório imediato, primeiro e segundo, os níveis de hematócrito e da hemoglobina foram maiores e significativos na minicirculação extracorpórea que no circulação extracorpórea, embora o sangramento no primeiro e segundo dias pós-operatórios tenha sido maior e significativo no minicirculação extracorpórea que no circulação extracorpórea.Conclusão:Os resultados sugerem que a minicirculação extracorpórea foi benéfica em reduzir a transfusão de células vermelhas do sangue durante a cirurgia e houve discreta, mas significativa, elevação do hematócrito e hemoglobina no pós-operatório.

Goal-directed hemostatic therapy using the rotational thromboelastometry in patients requiring emergent cardiovascular surgery.

Aims and Objectives: We assessed the clinical impact of goal‑directed coagulation management based on rotational thromboelastometry (ROTEM) in patients undergoing emergent cardiovascular surgical procedures. Materials and Methods: Over a 2‑year period, data from 71 patients were collected prospectively and blood samples were obtained for coagulation testing. Administration of packed red blood cells (PRBC) and hemostatic products were guided by an algorithm using ROTEM‑derived information and hemoglobin level. Based on the amount of PRBC transfused, two groups were considered: High bleeders (≥5 PRBC; HB) and low bleeders (<5 PRBC; LB). Data were analyzed using Chi‑square test, unpaired t‑test and analysis of variance as appropriate. Results: Pre‑operatively, the HB group (n = 31) was characterized by lower blood fibrinogen and decreased clot amplitude at ROTEM compared with the LB group (n = 40). Intraoperatively, larger amounts of fibrinogen, fresh frozen plasma and platelets were required to normalize the coagulation parameters in the HB group. Post‑operatively, the incidence of major thromboembolic and ischemic events did not differ between the two groups (<10%) and the observed in‑hospital mortality was significantly less than expected by the Physiological and Operative Severity Score for the enumeration of Mortality and Morbidity (POSSUM score, 22% vs. 35% in HB and 5% vs. 13% in LB group). Conclusions: ROTEM‑derived information is helpful to detect early coagulation abnormalities and to monitor the response to hemostatic therapy. Early goal‑directed management of coagulopathy may improve outcome after cardiovascular surgery.

Post-Operative Hemorrhage after Myomectomy: Safety and Efficacy of Transcatheter Uterine Artery Embolization

OBJECTIVE: To evaluate the safety and clinical efficacy of transcatheter uterine artery embolization (UAE) for post-myomectomy hemorrhage. MATERIALS AND METHODS: We identified eight female patients (age ranged from 29 to 51 years and with a median age of 37) in two regional hospitals who suffered from post-myomectomy hemorrhage requiring UAE during the time period from 2004 to 2012. A retrospective review of the patients' clinical data, uterine artery angiographic findings, embolization details, and clinical outcomes was conducted. RESULTS: The pelvic angiography findings were as follows: hypervascular staining without bleeding focus (n = 5); active contrast extravasation from the uterine artery (n = 2); and pseudoaneurysm in the uterus (n = 1). Gelatin sponge particle was used in bilateral uterine arteries of all eight patients, acting as an empirical or therapeutic embolization agent for the various angiographic findings. N-butyl-2-cyanoacrylate was administered to the target bleeding uterine arteries in the two patients with active contrast extravasation. Technical and clinical success were achieved in all patients (100%) with bleeding cessation and no further related surgical intervention or embolization procedure was required for hemorrhage control. Uterine artery dissection occurred in one patient as a minor complication. Normal menstrual cycles were restored in all patients. CONCLUSION: Uterine artery embolization is a safe, minimally invasive, and effective management option for controlling post-myomectomy hemorrhage without the need for hysterectomy.

Extracorporeal membrane oxygenation as a support for TGA/IVS with low cardiac output syndrome and pulmonary hemorrhage / Oxigenação extracorpórea por membrana como suporte para TGA/IVS com síndrome de baixo débito e hemorragia pulmonar

A 15-day-old neonate with complete transposition of the great arteries/intact ventricular septum was admitted with life-threatening hypoxemia and heart arrest. After successful resuscitation, heart beat recovered but blood lactate began to arise and maintained above 15 mmol/L 6 hours later. Emergency arterial switch operation was done at 20 hours after resuscitation. Planned extracorporeal membrane oxygenation support was employed postoperatively. The baby experienced severe pulmonary hemorrhage and severe hypoxemia after weaning from cardiopulmonary bypass, which were treated with extracorporeal membrane oxygenation support.

Um recém-nascido de 15 dias de idade, com transposição completa das grandes artérias/septo ventricular intacto, foi internado com hipoxemia com risco de vida e parada cardíaca. Após a reanimação bem sucedida, o coração voltou a bater, mas o lactato elevou-se e manteve-se acima de 15 mmol/L, 6 horas após. Operação de emergência para correção da transposição das grandes artérias foi realizada 20 horas após a ressuscitação. Suporte de oxigenação por membrana extracorpórea foi empregado no pós-operatório. O bebê apresentou hemorragia pulmonar e hipoxemia graves após desconexão da circulação extracorpórea, que foram tratadas com suporte da xigenação por membrana extracorpórea.

Role of tranexamic acid in reducing postoperative blood loss and transfusion requirement in patients undergoing hip and femoral surgeries

Pharmacological agents are used to reduce postoperative blood loss. To assess the effects of tranexamic acid on prevention of bleeding and requirement of blood transfusion after major hip and femoral surgeries. A prospective, randomized, double blinded study was conducted in the tertiary care teaching hospital. Ninety ASA grade I-II patients undergoing hip fracture surgery were included in this prospective study. Forty-five patients received tranexamic acid [TA] given in a bolus dose of 500 mg 15 min before surgical incision followed by continuous infusion. The remaining, 45 patients were allocated as a control group. Postoperative bleeding [volume of blood in the drain], percentage fall of hemoglobin, transfusions and complications were recorded. Mean volume of blood in the drain was 39.33 +/- 10.09 ml [mean +/- SD] as compared to 91.11 +/- 17.61 ml in placebo group showing a P<0.001. Mean percentage fall in Hb at day 0 was 2.99 +/- 3.45 in the study group as compared to 7.70 +/- 6.05 in the placebo group [P<0.001], and fall at day 2 in the study group was 0.35 +/- 0.74, compared to 2.72 +/- 2.70 in the placebo group [P<0.001]. The number of patients required blood transfusions were lower in the study group than in the placebo group [P=0.01]. We conclude that tranexamic acid significantly reduces postoperative blood loss and transfusion requirements during major hip and femoral surgeries

Complicaciones de la pancreatoduodenectomía, diagnóstico y manejo / Diagnosis and management of pancreatoduodenectomy complications

Pancreatoduodenectomy continues to have a high rate of complications. The most common and severe complications are intra or postoperative bleeding, pancreatic fistulae and derangements of gastric emptying. Each of these requires a great deal of clinical suspicion and an multidisciplinary management. This is a review of these complications, their clinical manifestations and their management.

A pesar de la disminución observada en las cifras de mortalidad de la pancreatoduodenectomía, continúa siendo una intervención asociada a una alta tasa de complicaciones. Las más comunes y asociadas a una mayor morbimortalidad son: el sangrado intra y post operatorio, la fístula pancreática y trastornos asociados al vaciamiento gástrico. Cada una de los eventos anteriores, requiere de un alto grado de sospecha clínica y de un manejo de tipo multidisciplinario. En este reporte se analizan las complicaciones anteriormente descritas, sus manifestaciones clínicas y los principios de su manejo.

Conduta no perioperatório de paciente pediátrico com trombastenia de glanzmann durante adenoidectomia / Perioperative management of a pediatric patient with glanzmann's thrombasthenia during adenoidectomy / Conducta en el perioperatorio de paciente pediátrico con trombastenia de glanzmann durante la adenoidectomía

JUSTIFICATIVA E OBJETIVOS: Trombastenia de Glanzmann (TG) é uma doença autossômica recessivamente hereditária das plaquetas. Não há nenhum tratamento específico. A transfusão de plaquetas é atualmente o tratamento padrão quando o sangramento não responde a medidas locais e/ou a medicamentos antifibrinolíticos, podendo, entretanto, resultar em aloimunização. O fator VII recombinante ativado (rFVIIa) pode ser usado para evitar a transfusão recorrente de plaquetas. RELATO DE CASO: Apresentamos um tratamento precoce com dose baixa de rFVIIa associada à transfusão de plaquetas em um caso pediátrico (cinco anos de idade), com diagnóstico de TG e apresentando sangramento prolongado durante adenoidectomia eletiva. Uma dose total de 1.200 mg (60 µg.kg-1) de rFVIIa obteve sucesso em estancar o sangramento, o que pode ser aceito como uma dose baixa. CONCLUSÕES: Relatos de casos podem encorajar o uso de tratamento precoce com baixas doses de rFVIIa em hemorragias graves que não estacam a despeito da transfusão de plaquetas e na prevenção de sangramento em procedimentos cirúrgicos em pacientes com TG. Estudos adicionais são necessários para definir a dose mínima eficaz. Portanto, as tentativas para determinar a dose eficaz mais baixa desse composto devem ser incentivadas consideando o resultado deste caso em face de restrições financeiras no sistema de saúde.

BACKGROUND AND OBJECTIVE: Glanzmann's thrombasthenia (GT) is an autosomal recessively inherited platelet disorder. There is not any specific treatment. Platelet transfusion is currently the standard treatment when bleeding does not respond to local measures and/or antifibrinolytic treatment, although it may result in alloimmunization. Recombinant activated factor VII (rFVIIa) might be used to avoid recurrent platelet transfusion. CASE REPORT: We present early treatment with low-dose rFVIIa additional to platelet transfusion in a 5-year-old pediatric case with diagnosis of GT who developed prolonged bleeding under an elective adenoidectomy surgery. A total dose of 1,200 µg (60 µg.kg-1) rFVIIa could successfully stop bleeding, what can be accepted as low dose usage. CONCLUSIONS: Such case reports may encourage the use of early treatment with low doses of rFVIIa in severe bleeds that did not stop despite of platelet transfusion, as well as in preventing bleeding in surgical procedures in patients with GT. Actually, additional studies are needed to define the minimal effective dose and attempts to determine the lowest effective dose may be encouraged by the result of this case, considering financial restrictions in the health care system.

JUSTIFICATIVA Y OBJETIVOS: La Trombastenia de Glanzmann (TG) es una enfermedad autosómica recesivamente hereditaria de las plaquetas. No hay ningún tratamiento específico. La transfusión de plaquetas es hoy por hoy, el tratamiento estándar cuando el sangramiento no responde a medidas locales y/o a medicamentos antifibrinolíticos, pudiendo sin embargo, resultar en una aloinmunización. El factor VII recombinante activado (rFVIIa) puede ser usado para evitar la transfusión recurrente de plaquetas. RELATO DE CASO: Presentamos aquí un rápido tratamiento con una dosis baja de rFVIIa asociada a la transfusión de plaquetas en un caso pediátrico (5 años de edad), con diagnóstico de TG y presentando un sangramiento prolongado durante la adenoidectomía electiva. Una dosis total de 1.200 mg (60 µg.kg-1) de rFVIIa tuvo éxito al estancar el sangramiento, lo que puede aceptarse como una dosis baja. CONCLUSIONES: Relatos de casos pueden estimular el uso de tratamiento rápido con bajas dosis de rFVIIa en las hemorragias graves que no estancan, pese a la transfusión de plaquetas y a la prevención de sangramiento en los procedimientos quirúrgicos en pacientes con TG. Sin embargo, estudios adicionales se hacen necesarios para definir la dosis mínima eficaz. Por tanto, los intentos para determinar la dosis eficaz más baja de un compuesto tan caro deben ser incentivados debido al resultado de este caso cuando existan restricciones financieras en el sistema de Sanidad.

Red cell transfusion; triggers used in operating room

The purpose of this study was to determine and quantify those factors that anesthetist's use when deciding to transfuse blood in operating room. CMH abbottabad Nov to Dec 2008. Survey report. Prospective cross-sectional descriptive from operation theatre of Combined Military Hospital Abbottabad a tertiary care hospital. With consent from the local ethics committee, an audit was carried out using a questionnaire designed to examine some of the factors that could be important in the decision-making process surrounding blood transfusion during intermediate and major surgery. Anesthetists were asked to fill in the audit forms and to indicate whether they were going to give blood or not. Fifty two audit forms, completed during intermediate or major surgery, were analyzed to determine the strengths of certain factors in the decision-making process related to transfusion. Fifty one forms had a satisfactorily complete data set with hemoglobin concentrations Hb between 6.6 and 15.0 g/dL. This study demonstrates that, of the physiological factors, the hemoglobin concentration was the most important factor used for red cell transfusion, and the presence of ongoing bleeding an important contextual factor. Peer pressure to transfuse became apparent at a [Hb] of about 8.5 g/dL. The patients were transfused at the average Hb value of 10.8 g/dL. This average Hb of transfused patients is much higher than current Hb trigger thresholds of 7.0-8.0 g/dL

[Post operative bleeding: prevention, diagnosis, treatment in time]

Nowadays by the new methods of the surgery and by decreasing it's complications more patients could be candidate for surgery but one of the existing complications that the surgeons should know it as much as possible is post operation bleeding. They should try to gain enough knowledge in order to be able to screen the high risk patient and prevent postoperative bleeding. By all these surgeons if patient had bleeding during the surgery and after that, surgeons should know how to control it and choose the best way to have less complications and more effective treatments

Nasal packing in cosmetic and functional nasal surgery

To evaluate the routine use of nasal packing after cosmetic and functional nasal surgery. Prospective collection from 2005 to 2006 at King Abdulaziz University Hospital in Riyadh for 54 patients post-septorhinoplasty with and without submucous diathermy or lateralization of inferior turbinate were evaluated for efficacy and complications of nasal packing which kept for different duration. All 54 patients had septoplasty, 21 with rhinoplasty, 12 with SMD, and 24 patients had inferior turbinate lateralization. Eight cm slim Merocel packed in 67 nasal cavity sides, 8 cm regular Merocel packed in 24 sides and 10 cm regular Merocel packed in 6 sides. Thirty-seven patients had the pack for 6 hours then removed and 17 patients had it for 24 hours. Forty-one patients with no significant discomfort, 13 patients with mild to moderate discomfort. Septorhinoplasty and SMD or lateralization of inferior turbinate can be managed without packing or any other hemostatic measures

Comparison of suture ligation versus electrocoagulation in controlling post tonsillectomy bleeding

Postoperative hemorrhage is one of the most common serious complications after adenotonsillectomy requiring proper management during and after surgery. This study was conducted to compare effects of electrocoagulation versus suture ligation on control of bleeding after tonsillectomy. This was a blind randomized control trial study including children schedueled for tonsillectomy in Tohid hospital in Sanandaj from April 2004 to May 2006. 110 patient were entered into the study. Surgical indications were tonsillar hypertrophy with obstructive symptoms and recurrent tonsillitis. Method of anesthesia was the same for all the patients and method of surgery was dissection by use of snare. All operations were performed by the same surgon. To control bleeding, suture ligation was used for the left and electrocoagulation for the right side of the operation site in the same patient. The sites of electrocoagulation and suture ligation were alternately changed in the next patients. The time spans required for suture ligation or electrocoagulation, primary and secondary postoperative bleeding, local and recurrent pain, formation of whitish memberane along with its sloughing and cicatrization of tonsillar fossa were recorded. The collected data were analyzed by use of SPSS win and x[2] and t-student tests. 46 female and 64 male patients, with mean age of 9 +/- 2.7 years were entered into this study. The overall primary and secondary postoperative bleeding rate was 1.8% and 2.7% respectively. Primary bleeding in electrocoagulation site included 0.9% and in suture ligation site 0.9% [p<0.05]. All the cases of the secondary bleeding occurred in suture ligation site [p<0.05], massive bleeding was detected in 0.9% of the patients, all of them in the electocoagulation sites. There were no significant correlation between pain after tonsillectomy, recurrent pain, duration of cicatrisation and method of haemostasis [p>0.05]. Results of the study showed no significant difference between electrocoagulation and suture ligation in controling post tonsillectomy bleeding, but secondary bleeding in electrocoagulation was less common than that in suture ligation. In order to control bleeding from vessels, suture ligation is more suitable than electrocoagulation

Incidence of postoperative tonsillectomy bleeding: coblation versus noncoblation

Tonsillectomy and adenoidectomy continue to be the most frequent surgical procedures performed by otolaryngologists for the resolution of upper airway obstruction or recurrent or chronic throat infections and for management of recurrent childhood ear disease. It accounts for around 30% of the operations they perform, with haemorrhage being the most common and serious complication following tonsillectomy and represents about 78% of readmissions within 28 days of surgery. The reported incidence of post-tonsillectomy secondary haemorrhage varies remarkably, from 0.8 per cent to 18 per cent, depending largely on the size and age of the population measured and the definition of 'bleeding' employed. The operating principle of coblation or electrodissociation is similar to bipolar diathermy or electrosurgery. By coblation the medium is dissociated into free sodium ions, which are responsible for the destruction of intercellular bonds, resulting in tissue dissociation. This reaction is achieved at temperatures between 60 °C and 70°C with minimal collateral thermal tissue damage. Also, the presence of cool, irrigating isotonic saline helps to limit the amount of heat delivered to the surrounding structures. It is the duty of the surgeon to ensure that optimal methods are being used and to assess the utility and safety of any new technology in his field. So, the next logical step in the evaluation of coblation tonsillectomy is to determine the postoperative complication rate. The aim of the present study was to compare the rates of reactionary and delayed hemorrhage between coblation tonsillectomy and the standard dissection technique, this study was also designed to attempt to determine whether a learning curve exists with regards to postoperative bleeding when using this new coblation technique. The present study reviewed tonsillectomies performed from August 2002 to end of 2005 in the International Hospital of Bahrain. The new technique using tissue coblation for tonsil dissection offers significant advantages in the postoperative period compared with dissection tonsillectomy with bipolar diathermy hemostasis. Coblation is associated with a lesser incidence of delayed hemorrhage that is more significant in the children population. Comparing the skill of an operator using a well-practiced technique and a new technology must surely introduce a bias in favor of the established technique. As with all new technology, there is a learning curve after which the technique is mastered and morbidity reduced to a minimum